The process of laboratory/point-of-care testing of patient samples comprises three distinct phases: the preanalytical phase, which includes sample collection and transport to the site of testing; the analytical phase; and the postanalytical phase, which includes communication and interpretation of the test result as...

Intravenous (iv) catheters are routinely employed for speedy delivery of fluids and drugs to the critically ill; they also provide the means for sampling blood for testing. This iv catheterization occurs in a range of settings including prehospital emergency care, hospital emergency rooms and intensive/critical care...

Raised plasma/serum potassium (hyperkalemia), which is widely defined as potassium >5.0-5.3 mmol/L, is a common electrolyte disturbance with many possible causes, including renal failure, acidosis, aldosterone deficiency and tissue damage. Severe hyperkalemia is a potentially life-threatening condition that demands...

Plasma calcium is maintained within normal limits by the integrated action of three hormones: parathyroid hormone (PTH); the vitamin D-derived renal hormone, calcitriol; and the thyroid hormone, calcitonin.  Hypocalcemia (reduced blood calcium), which is defined as corrected total plasma calcium <2.20 mmol/L and...

In health plasma potassium concentration is maintained within the approximate reference range of 3.5-5.3 mmol/L in part by the action of the adrenal hormone aldosterone on renal tubule cells. Hypokalemia (reduced blood potassium), defined as plasma potassium <3.5 mmol/L, is one of the most common electrolyte...

As the authors of this review article acknowledge, chronic kidney disease (CKD) is a growing public health burden around the world. Recent study, cited by the authors, suggests an estimated 14 % of the US population are now diagnosed with CKD, and 0.2 % have end-stage renal disease (ESRD), the most severe presentation ...

In health plasma ionized calcium concentration (iCa) is maintained within the approximate reference range of 1.15-1.30 mmol/L (4.6-5.2 mg/dL) principally by the synergistic action of two hormones: parathyroid hormone (PTH) and the vitamin D-derived hormone, calcitriol.  Hypercalcemia (increased blood calcium),...

Monitoring patient acid-base status is one of three principal clinical utilities of blood gas analysis (the other two are monitoring patient oxygen and ventilation status). Three parameters generated during blood gas analysis (pH, pCO₂ and bicarbonate) allow this acid-base assessment and classification of all...

In health plasma potassium concentration is maintained within the approximate reference range of 3.5-5.2 mmol/L, so that hypokalemia (reduced plasma potassium) is defined as plasma potassium < 3.5 mmol/L.  Mild hypokalemia (plasma potassium in the range of 3.0-3.5 mmol/L) is a common electrolyte disturbance that may or ...

It is commonplace for clinical staff tasked with blood sample collection to ask patients to make a fist before venipuncture; it reportedly helps by making veins more visible. Patients may also be asked to maintain a clenched fist during the procedure. This practice of ”fist clenching” is sanctioned in phlebotomy...