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Chronic kidney disease (CKD): a study of prevalence in the community

Frequent point-of-care creatinine measurement in the critically ill allows early prediction of AKI

Because measurements of GFR are tedious, estimated GFRs based on creatinine or cystatin C are widely used for assessing kidney function. Both measured GFRs and the Staging System for CKD based on GFR have analytical and clinical shortcomings. The advantages of serum creatinine and cystatin C, and eGFR will be...

Acute kidney injury (AKI) is defined as an abrupt decrease in kidney function evidenced by recent (within 48 hours) increase in serum creatinine concentration equal to or greater than 26.5 µmol/L (0.3 mg/dL). It can be a complication of many conditions that warrant hospital admission so it is common; up to 20 % of...

As the authors of this review article acknowledge, chronic kidney disease (CKD) is a growing public health burden around the world. Recent study, cited by the authors, suggests an estimated 14 % of the US population are now diagnosed with CKD, and 0.2 % have end-stage renal disease (ESRD), the most severe presentation ...

This second of two articles on understanding the clinical value of measuring urea concentration explores the clinical value of simultaneous measurement of urea and creatinine and calculating the urea:creatinine ratio. The article discusses the causes of increased and decreased ratio as well as the clinical application ...

This first of two articles on understanding the clinical value of measuring urea concentration dives into the physiological topics, such as urea production and renal processing of urea as well as the causes of increased and reduced urea concentration. Kidney disease is associated with reduced urea excretion and...

Glomerular filtration rate (GFR) is a parameter of prime clinical significance because it defines kidney function. All those with reduced kidney function, no matter what the cause, have reduced GFR, and GFR correlates well with disease severity. The most accurate assessment of GFR is thus valuable not only for early...

Routine laboratory assessment of renal function depends on estimating glomerular filtration rate from serum creatinine concentration. Serum creatinine concentration is age- and gender-dependent. A recently published study aimed to establish age-stratified and gender-specific reference intervals for serum creatinine...