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Articles and journal scans about Preanalytical phase
Journal Scan
July 2019
Preanalytic error in plasma/serum glucose measurement examined
Accurate estimation of in vivo blood glucose concentration is potentially compromised by in vitro glycolysis, the temperature- and time-dependent enzymatic metabolism of glucose by blood cells after blood is removed from the body.
For more than 40 years it was recommended that in order to avoid the potential problem ...
Preanalytical phase
Process optimization
Glucose
Journal Scan
December 2018
An assessment of variability in plasma potassium measurement
Data collected during a multicenter phase-3 clinical trial of a novel drug treatment for hyperkalemia (raised blood potassium) has provided a serendipitous opportunity to examine the variability of plasma potassium measurement. The trial required recruitment of patients with plasma potassium in the hyperkalemic range...
Preanalytical phase
Quality assurance
Electrolytes
Journal Scan
September 2018
Reducing risk of iatrogenic anemia by revising phlebotomy practice
A simple change in phlebotomy practice – switching from conventional to low-volume sample blood tubes – results in a 42 % reduction in patient blood loss, and consequent reduced risk of iatrogenic anemia. That is the positive headline finding of this recently published study conducted at the Royal Adelaide Hospital in ...
Process optimization
Preanalytical phase
Article
September 2018
Pseudohyperkalemia
In health plasma/serum potassium (K+) is maintained within the approximate reference range of 3.5 to 5.2 mmol/L, with serum values being slightly higher (∼ 0.4 mmol/L) than those of plasma because the process of blood clotting, essential to recovery of serum samples, is associated with release of potassium from...
Preanalytical phase
Electrolytes
Article
July 2018
Patient Blood Management – the importance of hemoglobin measurement and minimizing phlebotomy-associated iatrogenic blood loss
Transfusion of donated (allogenic) red blood cells is of undoubted life-saving benefit to those suffering rapid and massive blood loss (hemorrhage) due to major trauma, or complications during surgery and childbirth. However, the procedure is not without risk, and accumulated evidence over the past 2 decades has...
Point-of-care testing
Blood gases/acid-base
Preanalytical phase
Journal Scan
March 2018
Albumin adjustment of total calcium not justified
Almost all (99 %) of the approximate 1 kg of calcium in the adult human body is contained in bone, but a small fraction (approximately 350 mg) circulates in blood plasma at a concentration of around 2.5 mmol/L. This circulating calcium comprises three fractions: around half (50 %) is free ionized calcium; the rest is...
Preanalytical phase
Process optimization
Journal Scan
January 2018
Acid-base and electrolyte disturbance in chronic kidney disease – a themed issue review
As the site of production of the hormones: renin, erythropoietin and calcitriol that regulate, respectively, blood pressure, erythrocyte (red blood cell) production and absorption of dietary calcium, the kidneys have significant and disparate endocrine function. Additionally, of course, the kidneys have an excretory...
Blood gases/acid-base
Preanalytical phase
Process optimization
Quality assurance
Journal Scan
December 2017
Pseudohyperkalemia: a clinical study
Raised plasma/serum potassium (hyperkalemia), which is widely defined as potassium >5.0-5.3 mmol/L, is a common electrolyte disturbance with many possible causes, including renal failure, acidosis, aldosterone deficiency and tissue damage. Severe hyperkalemia is a potentially life-threatening condition that demands...
Preanalytical phase
Electrolytes
Journal Scan
June 2017
Potential preanalytical error in arterial blood gases examined
The gold standard sample for blood gas analysis is arterial blood. Compared with collection of venous or capillary blood, collection of arterial blood by arterial puncture is a painful procedure that can induce feelings of anxiety. The notion that this pain and anxiety could be a source of preanalytical error in blood ...
Blood gases/acid-base
Preanalytical phase
Journal Scan
April 2017
Phlebotomy recommendation reiterated
It is widely acknowledged that the majority of errors in clinical laboratory and point-of-care testing occur during the preanalytical phase. Blood collection (phlebotomy) is an element of the preanalytical phase particularly prone to potential error, so that adherence to authoritative (evidence-based) recommendations...
Preanalytical phase
Process optimization