In 2001 a landmark study demonstrated that normalization of blood glucose significantly reduces mortality and morbidity among intensive care patients. Now 5 years on, strict control of blood glucose concentration with insulin therapy is accepted as an imperative of optimal intensive care in many hospitals around the...

Measurements of pH, pCO₂ and pO₂ of arterial blood during blood gas analysis are all made at normal body temperature, 37 °C. The sample is warmed to that temperature prior to analysis. Blood gas analyzers provide the option for these primary measurements to be automatically "corrected" to the patient’s actual body...

Modern blood gas analyzers have incorporated technology that allows spectrophotometric measurement of bilirubin concentration on the same whole-blood sample that is used to measure blood gas parameters. A recent French multicenter study confirms the reliability of this technique for measuring bilirubin during the...

Hemorrhage, due to a reduction in the coaguability of blood, is a common cause of morbidity and mortality among trauma victims and the critically ill in general. Reduced blood pH (acidosis) is also common in these patient groups. Previous studies have shown that acidosis is an independent risk factor for development...

Pulse oximetry provides the means for continuous non-invasive monitoring of oxygen saturation (SpO₂). Although not currently used for the purpose, recent international guidelines suggest that pulse oximetry may be useful in the assessment of newborns who require urgent resuscitative measures at the time of birth....

Conventionally, arterial blood is sampled for blood gas analysis, but if the purpose is to assess acid-base balance, venous blood may be an acceptable alternative. That is the main conclusion of a recently published study conducted at the intensive care units of two Melbourne hospitals.  The objective of the study was ...

Reduced blood glucose (hypoglycemia) is one of the more common metabolic emergencies during the neonatal period, which in a small minority of cases results in permanent brain damage. It remains unclear how low blood glucose concentration must fall for such devastating effect. This gray area of understanding is...

Transient hyperglycemia (raised blood glucose concentration) is a common feature of serious acute illness, including myocardial infarction. For many years, this so-called "stress hyperglycemia" was considered of little clinical significance unless it was particularly severe (blood glucose > 12 mmol/L) or associated...

How to implement improvements in hospital settings within a week Jens Weirsøe is one of Radiometer's most experienced Master Black Belts in Transactional Process Improvements (TPI or kaizen). He has facilitated 90 kaizen events in several countries (USA, Japan, Germany and Denmark), in several different industry...

This is the forth and final essay in a series of four essays on www.acutecaretesting.org.  The first essay, "Quality control in theory and practice – a gap analysis", raised the question: Has “the system” given front-line laboratory workers the knowledge and tools they need to make quality control decisions wisely? Or ...