Measurement of blood lactate provides clinicians with a valuable means of identifying and monitoring critically ill patients who are suffering clinical shock as a result of severe trauma, sepsis or cardiogenic shock. Lactic acid accumulates in the blood of these patients due to the tissue hypoxia that results from...

This is the second of two articles about the risks and benefits of red-cell transfusion directed at healthcare professionals without any particular transfusion expertise. The focus of the first article was the risks and the extensive measures taken to minimize those risks. For this second article, attention turns to...

When blood gas analysis reveals a reduced pO₂(a) in a patient without any immediate clinical evidence of hypoxemia, consideration should be given to the possibility that the result is falsely low, allowing a diagnosis of spurious or pseudo-hypoxemia.  Technical deficiencies (e.g. sampling of venous rather than...

The standard sample for measurement of blood gases is arterial blood. Arterial puncture is painful and, because of inherent dangers, is usually only performed by qualified medical staff. Arterialized earlobe capillary blood sampling provides a less painful and safer alternative, which can be reliably performed after...

There is widespread confusion concerning the quantities to be used in the description of the oxygen-transport properties of human blood [1]. It all began in 1980 with the introduction of a changed (and wrong) definition of oxygen saturation in a paper on a new instrument for multicomponent analysis (MCA) of...

Although often of life-saving benefit, transfusion of donated red cells is associated with considerable potential risk for the recipient patient. This article, directed at healthcare professionals without any particular transfusion expertise, outlines these risks and the measures taken to minimize them. Particular...

Interview Fetal scalp Blood Sampling (FBS) – not exactly wishful thinking for the mother, nor for the obstetrician? The procedure is regarded as cumbersome, the sample quality is questionable and the consequences of the result may be instrumental vaginal delivery or Cesarian Section (CS). acutecaretesting.org has...

Reprinted with permission from Elsevier from "Neonate capillary blood gas reference values", by Jocelyne Cousineau, Suzanne Anctil, Ana Carceller, Monique Gonthier and Edgard E. Delvin, CLINICAL BIOCHEMISTRY, Vol no 38, 2005, pp 905-907. Copyright 2005 by Canadian Society of Clinical Chemists. OBJECTIVES Because...

Hemoglobin is the oxygen-carrying protein contained in red blood cells (erythrocytes). Although normally present in only trace amounts, there are three species of hemoglobin that cannot transport oxygen.  The three species, collectively called dyshemoglobins because of their functional redundancy, are methemoglobin,...

The collection of arterial specimens with glass syringes and immediate storage in iced water was the accepted industry standard for many years. Practice has changed over the past several years to blood gas sample collection in plastic syringes, likely due to the cost, safety and convenience of plastic. This change ...