A significant increase in the use of blood tests for the management of trauma patients has had little overall effect in terms of survival following trauma, or the length of time those who survive have to spend in hospital.  This is a headline finding from a recently published study examining the clinical impact of...

The clinical value of any patient test result depends on the quality of the reference interval used for its comparison (interpretation), so that good laboratory medicine practice demands continuous review of reference intervals. There is a paucity of published study aimed at validating the health-associated reference...

Plasma bicarbonate concentration, a parameter generated during arterial blood gas analysis, is essential to the assessment of patient acid-base status. Blood gas analyzers do not have the capacity to directly measure bicarbonate; instead, it is calculated from measured pH and pCO₂(a), using the Henderson-Hasselbalch...

Although arterial blood remains the gold standard sample for blood gas analysis, it is, compared with peripheral venous blood, a more difficult sample to obtain, and its collection is more painful and hazardous for the patient. These considerations have fuelled a growing interest in study aimed at establishing if...

Blood gas analysis (BGA) provides the means for the most accurate assessment of patient oxygenation status; the two relevant blood gas parameters being partial pressure of oxygen in arterial blood (pO₂(a)), and % hemoglobin oxygen saturation (sO₂(a)).  Pulse oximetry, a technology now ubiquitous in all areas of...

The 1999 US Institute of Medicine report "To Err is Human: Building a Safer Health Care System" provided an influential wake-up call for healthcare workers concerning the frequency of preventable medical errors. Initiatives over the past decade aimed at improving the safety of patient-sample testing represent just...

Point-of-care testing sites continue to increase in number due to the availability of easy-to-use devices that make it possible to provide test results very quickly relative to the central laboratory services. There is, however, mixed review regarding the accuracy and reliability of POCT results for patient care. It...

In the intensive care unit blood is frequently sampled for arterial blood gases via an indwelling arterial catheter. Around a third of critically ill patients have such catheters inserted; they allow not only easy access for blood sampling but also continuous monitoring of blood pressure. In a short editorial the...

If the results of a recent New Zealand study are representative, there is room for improvement in the quality of blood gas test result interpretation among emergency-room medical staff. A total of 80 emergency-room doctors (37 consultants and 43 emergency-medicine trainees) voluntarily submitted themselves for a...

Arterial blood gas analysis includes measurement of partial pressure of oxygen (pO₂(a)) and calculation of oxygen saturation (sO₂(a)), both useful for assessing patient oxygenation status. Hypoxemia is diagnosed if pO₂(a) is below the lower limit of the reference range (10.6 kPa, 88 mmHg). Pseudo-hypoxemia is...