Millions of times every day, in a myriad of distinctive laboratories around this globe, front-line workers make the final decision on the quality of results they report. If they decide the quality is “OK”, patient results are released to impact clinical decisions, and proficiency values reflect the overall ability...

Reprinted with permission from Elsevier from "Neonate capillary blood gas reference values", by Jocelyne Cousineau, Suzanne Anctil, Ana Carceller, Monique Gonthier and Edgard E. Delvin, CLINICAL BIOCHEMISTRY, Vol no 38, 2005, pp 905-907. Copyright 2005 by Canadian Society of Clinical Chemists. OBJECTIVES Because...

Interview Fetal scalp Blood Sampling (FBS) – not exactly wishful thinking for the mother, nor for the obstetrician? The procedure is regarded as cumbersome, the sample quality is questionable and the consequences of the result may be instrumental vaginal delivery or Cesarian Section (CS). acutecaretesting.org has...

Assessment of patient acid-base status is one of the principal uses of arterial blood gas analysis. Disturbance of acid-base, usually the result of abnormal accumulation of metabolic acids, most notably lactic acid, is a relatively frequent finding among critically ill patients.  Base deficit (BD), a blood gas...

Massive hemorrhage is a major cause of morbidity and mortality among critically ill patients. Conventional treatment is based on surgical control of bleeding and transfusion of blood products including red cells, platelets and fresh frozen plasma. Despite optimal conventional care, bleeding sometimes proves impossible ...

Hailed by UK diabetic expert Professor Harry Keen as "one of the most important studies ever done for people with diabetes" when it was published in 1993, this influential clinical study was conducted by the Diabetes Control and Complications Trial Research Group (DCCT).  It settled once and for all a debate that had...

The results of the above trial suggest that administration of rFVIIa would reduce patient exposure to the perils of blood-product transfusion, which are only now being fully recognized.  Increased awareness of the morbidity and mortality associated with transfusion of blood products has led to the implementation of...

Investment in medical research is expected to have a payback; we assume that with the passage of time increased knowledge and understanding of disease process will inevitably lead to improved treatment and better outcome. This optimistic paradigm has proved valid for some of the major killer diseases, including heart...

Lack of homogeneity of a blood sample can lead to incorrect results. In this paper, the quality requirements of a sample prior to mixing, the type of samples, sample collection devices and tools and mechanics of mixing will be highlighted. Issues related to the mixing of samples intended for hematological and blood...

Iatrogenic phlebotomy loss resulting from the intensive clinical monitoring in the weeks immediately following birth remains the primary cause of neonatal anemia and the need for red-blood-cell (RBC) transfusion. Reducing RBC transfusion needs in the neonatal intensive care unit (NICU) requires new approaches for...