The principal function of the protein hemoglobin contained in red blood cells is transport of oxygen in inspired air from lungs to tissue cells. Although normally present in only trace amounts, there are three species of hemoglobin that cannot transport oxygen. The three species, collectively called the dyshemoglobins ...

What does it take to create and maintain a quality point-of-care program in a world-renowned healthcare institution? acutecaretesting.org recently asked that question to Paula Santrach, MD, Interim Chair of the Dept. of Laboratory Medicine and Pathology at the Mayo Clinic in the US. She came back with a list* of 10...

The National Academy of Clinical Biochemistry has developed a Laboratory Medicine Practice Guideline for point-of-care testing (POCT). This POCT guideline systematically reviews the scientific literature linking POCT to patient outcome and makes recommendations for the optimal use of POCT in patient care.  This...

In Geneva in 1821, a French nobleman Jacques Alexandre Le Jumeau, Vicomte de Kergaradec, became the pioneer of modern fetal monitoring. He described the sound of the fetal heartbeat, as he used the newly invented stethoscope (by Laennec, France 1819) and applied it to the abdominal wall of a pregnant woman [1]. The...

As point-of-care testing (POCT) continues to expand in the hospital environment, the desire of physicians to participate in the performance of testing may increase. This article discusses the required competencies for a physician who wishes to be involved in laboratory testing and some practical considerations for...

Although creatinine clearance has been the mainstay for estimating glomerular filtration rate (GFR) in laboratories for the past half-century, prediction equations based on serum creatinine and other routine serum analytes are now available which enable reporting of a calculated GFR using the Modification of Diet in...

Reprinted with permission from British Journal of Nursing, 2004, Vol 13, No 9.  Arterial puncture is the most common method used to obtain a sample for the measurement of arterial blood gases (ABGs) and is essential to guide the prescription of long-term oxygen therapy (LTOT) in patients with chronic hypoxic lung...

This is the third in a series of four essays on www.acutecaretesting.org.  The first essay, "Quality control in theory and practice – a gap analysis", raised the question: Has “the system” given front-line laboratory workers the knowledge and tools they need to make quality control decisions wisely? Or is there a...

The National Kidney Disease Education Program (NKDEP) Laboratory Working Group reviewed problems related to serum creatinine measurement for estimating glomerular filtration rate (GFR) and prepared recommendations to standardize and improve creatinine measurement. The NKDEP recommends using the estimating equation...

This is the second of two articles about the risks and benefits of red-cell transfusion directed at healthcare professionals without any particular transfusion expertise. The focus of the first article was the risks and the extensive measures taken to minimize those risks. For this second article, attention turns to...