There is widespread confusion concerning the quantities to be used in the description of the oxygen-transport properties of human blood [1]. It all began in 1980 with the introduction of a changed (and wrong) definition of oxygen saturation in a paper on a new instrument for multicomponent analysis (MCA) of...

Although often of life-saving benefit, transfusion of donated red cells is associated with considerable potential risk for the recipient patient. This article, directed at healthcare professionals without any particular transfusion expertise, outlines these risks and the measures taken to minimize them. Particular...

Reprinted with permission from Elsevier from "Neonate capillary blood gas reference values", by Jocelyne Cousineau, Suzanne Anctil, Ana Carceller, Monique Gonthier and Edgard E. Delvin, CLINICAL BIOCHEMISTRY, Vol no 38, 2005, pp 905-907. Copyright 2005 by Canadian Society of Clinical Chemists. OBJECTIVES Because...

Hemoglobin is the oxygen-carrying protein contained in red blood cells (erythrocytes). Although normally present in only trace amounts, there are three species of hemoglobin that cannot transport oxygen.  The three species, collectively called dyshemoglobins because of their functional redundancy, are methemoglobin,...

Iatrogenic phlebotomy loss resulting from the intensive clinical monitoring in the weeks immediately following birth remains the primary cause of neonatal anemia and the need for red-blood-cell (RBC) transfusion. Reducing RBC transfusion needs in the neonatal intensive care unit (NICU) requires new approaches for...

Lack of homogeneity of a blood sample can lead to incorrect results. In this paper, the quality requirements of a sample prior to mixing, the type of samples, sample collection devices and tools and mechanics of mixing will be highlighted. Issues related to the mixing of samples intended for hematological and blood...

Anemia is the collection of signs and symptoms of reduced oxygen delivery to tissues as a result of a reduction in the number of red cells and/or reduction in blood concentration of hemoglobin. In clinical practice, anemia is diagnosed if the blood concentration of hemoglobin (ctHb) is abnormally low.  The World...

The collection of arterial specimens with glass syringes and immediate storage in iced water was the accepted industry standard for many years. Practice has changed over the past several years to blood gas sample collection in plastic syringes, likely due to the cost, safety and convenience of plastic. This change ...

Point-of-care testing (POCT) results, like other forms of laboratory data, hold potential hidden information that can be utilized to improve patient care.  The technique of extracting useful information from vast amounts of data is termed “data mining”. Technological solutions are now available to meet the challenges ...

Test results are commonly interpreted against population-based reference (normal) intervals, which should be provided on every laboratory report, irrespective of whether the test has been done as point-of-care testing or in a clinical laboratory. Reference intervals are difficult to generate properly if international ...