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Articles
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Article
June 2001
Establishment of "metrological traceability" for quality control materials and calibrators
The concept of “metrological traceability” is important when establishing comparable clinical decision limits for a measured analyte at different hospitals within one country and in different countries.
This can only be achieved if all instrument manufacturers establish the performance characteristics of their...
Kidneys/fluids
Quality assurance
Article
June 2001
Quality planning and control strategies
What quality is being controlled in laboratories today? The definition of a quality requirement for each laboratory test is the starting point of quantitative quality management.
Different types of requirements may be used as long as there are appropriate quality-planning models for translating those requirements...
Quality assurance
Article
June 2001
The quality of diagnostic samples
While analytical quality standards seem well established, there has been a paucity in the development of such standards for the preanalytical phase.
Technical recommendations regarding sampling, transport, and identification have been developed in national (NCCLS, DIN) and international (IFCC, ISO) consensus...
Preanalytical phase
Quality assurance
Glucose
Lactate
Hemoglobins
Article
June 2001
Quality in the small laboratory
How do small labs cope with the demands of modern quality assurance?
In this interview, Ruth Lock, head of the laboratory of the Anesthesiology and Intensive Care Dept. of the Copenhagen County Hospital in Glostrup, Denmark, tells how her lab keeps up with demands with the help of training and quality control.
Quality assurance
Hemoglobins
Article
June 2001
Biological variation and quality for POCT
The results of laboratory tests are used in many clinical settings. In the main, results obtained in point-of-care testing (POCT) are used either in monitoring or in diagnosis. Analytical quality does affect outcomes in these clinical situations.
Numerical estimates of the quality required for laboratory tests to...
Quality assurance
Article
February 2001
Hyperbilirubinemia and requirements to the determination of the concentration of bilirubin
60 % of all neonates develop jaundice during their first week of life and thereby run a risk of getting hyperbilirubinemia.
Although different approaches for establishing treatment criteria have been suggested, treatment of neonatal hyperbilirubinemia is usually still based on the measurement of total bilirubin...
Preanalytical phase
Bilirubin
Neonatology
Hemoglobins
Article
December 2000
Blood gases, acid-base balance, muscle mass and exercise capacity at the upper tolerable limit for humans of acute and chronic hypoxia
An altitude of 5,000 meters above sea level or just above is just about what humans can bear - be it during an acute ascent or for permanent living. This study describes how bodily functions of crucial importance to survival at high altitude adjust after abrupt exposure to severe hypoxia.
Blood gases/acid-base
Glucose
Article
December 2000
Myocardinal oxygen extraction after two months of adaptation to high altitude
Two months of acclimatization to high altitude leads to an adaptation of the aerobic capacity of the myocardium, characterized by an increased ability to extract O2 from the coronary vascular bed. An increased mitochondrial volume and activity of oxidative enzymes or improved diffusion conditions could be involved.
Point-of-care testing
Blood gases/acid-base
Lactate
Hemoglobins
Article
June 2000
Laboratory supervision of point-of-care blood gas
Providing continuous technical support and reliable test data collection for point-of-care blood gas testing is a difficult task for many laboratories. Here we describe how the implementation of an integrated instrument control and data management system for point-of-care blood gas testing has streamlined these...
Point-of-care testing
Glucose
Lactate
Hemoglobins
Article
May 2000
Measurement of transcutaneous oxygen tension in patients with diabetic foot complications
Examination of peripheral pulses and peripheral blood pressures are commonly used methods for investigation of macrocirculation. However, falsely elevated peripheral blood pressures may complicate the accurate prediction of ulcer healing in diabetic patients. Because tcpO2 also measures the nutritive skin capillary...
Blood gases/acid-base